Are you someone/do you know someone that has MS that went through puberty early?
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DoleDevotion
New User, Becoming EHEALTHy
Joined: 20 Apr 2008 Posts: 2
MS treatments and causes Posted: 04-20-08 22:04pm
Hi everyone. I have a friend that was very
recntly diagnosed with MS based on a bout
of optic neuritis and an MRI that showed a
few inactive lesions and one active one.
Since I heard the news, I've been doing
some reading up, but there are still a lot
of questions that I have.
First of all, my friend is female, 27
years old and she had some double vision
about a year ago that her physician
considers to be probably her first
episode. Her doctor put her immediatley on
betaseron injections, and from what I have
heard from her, he didn't really present
her with other options. I haven't really
seen too many people talking about
betaseron. Anybody have experience with
it and how it worked for them, expecially
anyone that took it newly diagnosed?
Anyone have any recommendations for
treatment for someone newly diagnosed that
doesn't know how their MS will really be
affecting them?
Does anybody have anything that they
regret doing or not doing when they were
first diagnosed or that they would change
if they could go back and do so?
Next I have a fiarly good understanding of
the theories of the processes that cause
MS, but I have some questions about MS
that i've been unable to find an answer
to. If MS involves the eating away of the
myelin sheath on nerves, then why is the
damage limited to the nerves in the
central nervous system? Why aren't
periferal nerves affected? Or are they
affected and I am mistaken?
They say that whatever immune response is
triggered in MS, or whatever substance in
the immune system is causing the damage is
present throughout the whole body and not
just in the brain and spinal column. So
has there been any research as to why the
damage is limited to just the central
nervous system. Is there some innate
difference in nerve cells in one place or
the other?
Also, I've read that everyone has, in
their immune system, the t-cell that have
the potential to attack nerve cells, they
just don't get "turned on" in most
individuals. But i've also read that
people with MS might have some issues with
the blood brain barrier, since lymphocytes
don't typically migrate into the brain.
So, if you took a person that didn't have
MS and stuck some of their lymphoctyes
into the brain, would it activate that
same immune response and do damage to the
myelin in them as well? In other words, do
people who do not have MS, simply don't
have it because their lymphoctyes stay out
of the brain? or would no immune response
occur anyway, even if the lymphocytes of
person without MS were introduced into the
cerebrospinal fluid?
I've also read about attempts at filtering
antibodies out of the blood stream, where
the blood is run through a machine and
back into the body, of which the results
were that it seemed to help but only for a
limited time. Does the body constantly
produce the components of the immune
system? Like T-cells, B-Cells, etc etc.
Do they only live for a limited time and
there is a a constant stream of new ones
being made, and that is why the blood
filtering only worked for a little while?
What about if you replaced all of
someone's blood with transfused blood from
a healthy individual, would the same thing
occur-- that there might be a temporary
improvement but that the healthy immune
components- or components that might
inhibit the irregular immune response that
might be present in the transfused
blood-would eventually die out and the
regular unhealthy parts of the immune
system would continue to be reproduced?
Just out of ignorance, is there such a
thing as a cerebrospinal fluid filtering?
Has it ever been tried? What about a
cerebrospinal fluid transfusion, like a
blood transfusion?
Has there ever been an attempt to
transplant brain cells, and if so, was
there a similar immune response to the
transplanted cells as you see in multiple
sclerosis?
I was also wondering if anyone has heard
anything about or has had done that new
test to see how the immune system is
functioning-called immuknow by cytex? It
was developed for transplant patients who
are on immunosuppresants to see what type
of drugs would work best for them and what
dosage is ideal. Do people with MS ever
take a maintence of immunosuppresants as a
transplant patient would?
Also I've heard that bone marrow
transplants may hold some promise as a
treatment for people effected with MS, but
I've had trouble really finding any recent
information about it. Does anyone know of
results of such studies or know of anyone
that's had that done?
Next, this is kind of an area that I don't
think has been looked into very much
lately at all but it interests me because
of what i see as the coincidental timing
of the development /appearance of MS most
occurs most often in young adulthood, and
the termination of the thymus's active
role in the regulatory development of
components of the immune sytem. There have
been studies that environmental factors
that change in the years before puberty,
can have a change on a person's risk
factor of developing MS. It then seems
possible to me that there could be
something that happens during puberty that
triggers the disease, or that the ending
of the period of the thymus being active,
ends the period when a person still has a
"chance" to develop the balance or
regulatory components needed to stay
healthy.
So, I've also read that they have tried
Thymus transplants, which didn't seem to
have much effect. Has there ever been
tried a simultaneous bone marrow and
thymus transplant of a immature thymus?
Also, have there been any studies done
that anyone knows of that explore
commonalities in people who develop MS?
Especially things that are in common that
happen before or during puberty? Well
I've actually heard that they think that
contracting Epstein Barr may have some
impact on the immune system that could
trigger MS. They have also done studies
about genetic components that may mean a
higher risk of developing MS. I've heard
they've identified at least one possible
genetic contributor. Have they done any
studies to see who or how many people have
this genetic characteristic in common, and
if so, tried to find differences between
someone with that genetic characteristic
that hasn't developed MS and someone that
has?
I've also heard that a deficiency in
Vitamin D may contribute to the risk of
developing MS. I know that exposure to
sun light helps the body develop vitamin
D, would using a lamp that is supposed to
simulate sunlight also do that?
I've also read that allergies to certain
food products could inhibit the absorption
of vitamin D. My friend had an allergy
that she attributed to oats and oat
products since she was young. I think she
told me that they tested her for food
allergies and didn't find any allergy to
oats but everytime she ate something like
oatmeal she would get sick (vomiting). Do
you think this might be significant to her
development about MS.
Another sort of unusual thing about my
friend is that she started puberty at a
fairly young age (around 9). Has this
ever been linked to MS as a risk factor?
I guess i'm just looking for some answers
though i know i'm unlikely to really find
any. But any information that anyone has
about the things i've asked would be very
much appreciated. The more answers the
better.
1. Multiple sclerosis is treated with
corticosteroids and beta-interferon.
Corticosteroids are immunosupresive drugs
used for treating the acute exacerbations
(relapses) of the disease especially for
treating the optic neuritis.
Beta-interferon (Betaseron) is
immunomodulating drug used for preventing
the new relapses of the disease. Other
medications and procedures like Glatiramer
acetate, intra venous imunoglobulines,
cyclophosphamide, aminopiridines,
hyperbaric oxygen-therapy may have some
positive effect but not that efficient and
proven like corticosteroids and
beta-interferon.
2. From the peripheral nerves only optic
nerve is affected. Other peripheral nerves
are not affected probably because
antibodies can't reach them because they
are produced and present only in the
liquor and not in the blood. Trigger might
be present all over the body but immune
response is limited only in the brain and
spinal tissue. Optic nerve is an exception
because its coverings are in contact with
the liquor from the sub-arachnoid space.
Allergen that provokes the immune response
is still unknown. Produced antibodies are
not specific so allergen can't be
identified. It is believed that allergen
is some structural protein of the myelin.
3. T-lymphocytes probably have the main
role in the MS pathogenesis. But
macrophages, microglia and B-lymphocytes
are also included in the process.
T-lymphocytes can enter the brain tissue
whenever there is some stimulation that
will call them. But only T-lymphocytes
that are specific for certain antigen will
come, not all. Specific antigen activates
the specific T-Lymphocyte and than this
activated T-lymphocyte induces the whole
inflammatory process. This is so called
inductor-T-lymphocyte. In normal
occasions, inductor-T-lymphocytes that are
specific for host's antigens either should
not exist or should be suppressed.
Presence of T-lymphocytes, that are
specific for some host's antigens, is
genetically determined. In case of MS,
people with certain genetic marks are
found to be more susceptible to develop MS
than people that don't have such genetic
characteristics. Even if such
inductor-T-lymphocytes, directed toward
own body structures (some myelin component
in case of MS), exist, there are another
specific T-Lymphocytes that serve to block
this process. These are called
suppressor-T-lymphocytes. It is found that
in MS there is a defect in the function of
the suppressor-T-lymphocytes.
4. Blood filtering for removing the
antibodies won't help because there is no
antibodies in the blood. Antibodies are
present only in the cerebro-spinal liquor
and brain tissue. Cells that are directly
involved in the abnormal immune process
(T-Ly, B-Ly, plasma-cells, macrophages and
microglia have limited life but new cells
are created all the time. Specific T and
B-Lymphocytes multiply from so called
memory-cells that are placed in the bone
marrow, lymph nodes and brain.
Memory-Lymphocytes are not directly
involved in the inflammatory process but
serve as a reserve for the active cells.
Whenever some specific memory-cell is
stimulated by some specific antigen it
starts to proliferate. Some of the new
created cells will become active and some
will stay calm waiting for the next
stimulation. Memory-cells are long-life
which means live as long as the whole body
lives.
5. Liquor filtrating does not exist but
even if possible the inflammatory cells
and antibodies in the brain tissue will
stay. There is no need of brain cell
transplantation because brain cells are
not killed but only their axons' myelin
coverings.
6. There is a great difference in the
immune response in the transplanted
patients and in patients with MS. In
transplanted patients the immune system
fights against the foreign antigens in the
transplanted organs which is completely
normal reaction. Immunosupresive therapy
here is used to decrease the normal immune
reactivity which also has some bad
consequences (vulnerability to infections.
In MS, immune system fights against normal
body components and immunosupresive
therapy has task to calm this abnormal
reaction.
7. Thymus is the place where T-lymphocytes
"learn" how to recognize the antigens and
also "learn" which antigens are foreign
and which are not. T-lymphocytes that are
specific for host's antigens are ether
destroyed or suppressed. Similar process
is happening in the bone marrow and
refers to the B-lymphocytes. This process
of lymphocyte maturation ends when thymus
stops functioning (before puberty). Any
damage of the thymus during lymphocyte
maturation may cause severe immune
deficit. Transplantation of the thymus and
bone marrow won't help because after
maturation all the clones of "memory"
cells populate the "secondary" lymph
organs: lymph nodes, lien, MALT etc.
8. People that wear these genes: HLA-A3,
HLA-B7, HLA-DR2 and HLA-DQw1 are
susceptible to develop MS. Viruses are
blamed for provoking many auto-immune
disorders including MS.
|
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Extremely EHEALTHy
Joined: 18 Mar 2004 Posts: 1195 Location: ,
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Re: MS treatments and causes Posted: 05-04-08 08:56am
DoleDevotion
wrote:
I've also heard that a deficiency in
Vitamin D may contribute to the risk of
developing MS. I know that exposure to
sun light helps the body develop vitamin
D, would using a lamp that is supposed to
simulate sunlight also do that?
I can't really answer the rest of your
post, but this is the one that I have been
focusing on. I had a bout of optic
neuritis four years ago, and with a family
history of MS (my father), the doctor
warned that I had a higher than average
likelihood of MS. He did not, however, at
this stage suggest any kind of MRI or
prescribe steroids -- about 50% of optic
neuritis is idiopathic.
My research into the issue ended up
focusing on Vitamin D, due to the
epidemiological studies linking incidence
of MS and distance from the
equator/altitude/consumption of oily fish:
there appears to be a very strong inverse
correletion between exposure to Vitamin D
and incidence of MS in a population.
Vitamin D regulates the immune system,
i.e. it doesn't boost it or suppress it,
but keeps it steady. If indeed MS is an
autoimmune response, then stablising the
immune system as much as possible may be a
critical factor. The possibility may be
that a genetic predisposition coupled with
inadequate Vitamin D exposure, or perhaps
an inherited inefficiency in processing
Vitamin D so that a higher intake is
necessary, may explain who gets MS.
Incidentally, because of the assiduous use
of sunblock and lack of oily fish in most
people's diets, a lot of people in
northern latitudes are actually deficient
in Vitamin D anyway.
Short answer to your question: everyone,
and particularly people who are
predisposed to MS should get at least 15
minutes exposure on bare face and arms to
the sun every day between 10 am and 3 pm.
This only works between April and October,
however. I don't think a daylight bulb
would be sufficient to create the effect
on the skinThe rest of the time, the
easiest thing to do is to take Vitamin D
supplements -- the minimum recommended
daily amount is 5 micrograms = 200 IU. I
take at least double that every day in the
winter. I also take additional fish oil,
linseed and selenium supplements. I would
add that in four years I have not had any
other MS symptoms -- this may be good
luck, or I may be helping it along.
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