She should see the doctor ASAP to have a blood test and ultrasound and to be sure she is not pregnant.
However, birth control pills can have a bad reaction in some women and cause pregnancy symptoms. This was the case with me. I did fine on the pill for years, then suddenly, my body just had it. I started having a ton of water retention in my feet, legs & hands (weight went up almost 20 lb. in 1 month due to retaining water), the area over my uterus got hard and bulgy, exactly the way it looks now that I am almost 6 months pregnant, my breasts got huge, I had crazy mood swings & anxiety, I started craving foods (especially milk, which I normally dislike the taste of). All that, and I wasn't pregnant, it was just my body's reaction to the pill.
I actually had a ton more symptoms on birth control pills than I have now that I actually AM pregnant!