Mechanism Proposed For Link Between Ru-486 And Fatal Infecti Posted: 08-05-05 20:32pm
The abortion drug mifepristone
(mifeprex,tm ru-486) has been linked to
rare cases of fatal bacterial infections,
but until now the connection has not been
clearly understood. In "pathophysiology
of mifepristone-induced septic shock due
to clostridium sordellii," author and
brown university professor ralph p.
Miech, md, phd, proposes two models of how
this devastating reaction may occur. The
article appears in the annals of
pharmacotherapy online and in the
journal's upcoming september print issue.
During an abortion, mifepristone works by
blocking the effects of progesterone,
shutting off nutrition to the placenta and
fetus. However, miech points out, the
antiprogesterone effects of mifepristone
also cause changes in the cervix that
allow c. Sordellii, a common vaginal
bacteria, to enter the cervical canal. C.
Sordellii thrives in this low-oxygen
environment and derives nutrition from the
decaying fetal tissue. Meanwhile, other
hormonal effects of mifepristone, known as
antiglucocorticoid actions, are taking
place throughout the body. Through two
models proposed by miech, these
antiglucocorticoid effects may interfere
with chemical regulators known as
cytokines, offsetting the delicate balance
between over- and under-activation of the
immune system. This disruption impairs
the body's ability to fight off c.
Sordellii and may help spread the
bacteria's toxic by-products, a
combination that sometimes results in
widespread septic shock.
At least 5 women in the us and canada have
died from septic shock after taking
mifepristone. C. Sordellii has been
linked to 3 of those cases, while the
bacteria remains unidentified in the
others. C. Sordellii infections are rare
outside of mifepristone use and have
proven particularly dangerous because they
often lack the usual warning signs, such
as fever and tenderness on examination.
In 2004, the labeling of mifepristone was
amended to include a black box warning
about bacterial infections, sepsis, and
death that may occur after use. A citizen
petition for withdrawal of mifepristone
from the us market has been submitted to
the fda. It cites numerous safety
concerns as well as procedural violations
that occurred during the drug's approval
process.
###
the annals of pharmacotherapy is a leading
peer-reviewed, international
pharmacotherapy journal for physicians,
pharmacists, and other healthcare
professionals. Published by harvey
whitney books company, for over 39 years
the annals has featured articles directly
related to the safe, effective, and
economical use of medications and related
devices in patient care. The journal's
editorial office is headquartered at 8044
montgomery road, suite 415, cincinnati,
ohio 45236-2919, usa. The journal is
available in print and online in full text
at www.Theannals.Com.
Apparently you don't care about the women
who have died from this. There have been
many drugs pulled off of the market
because they are unsafe..But since this
one helps people kill (oops..I mean have a
choice) it should stay no matter what the
consequences?
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paganangel
Experienced User , Rather EHEALTHy
Joined: 22 Jun 2005 Posts: 377 Location: VA
Posted: 08-06-05 09:16am
So it's apparent that you don't give a
shi* about the people that have died from
taking this. You are not pro-choice this
proves that you are pro-abortion.
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msrosie
Experienced User , Rather EHEALTHy
Joined: 02 Jan 2005 Posts: 369 Location: Ontario, Canada
Thanks: 12
Thanked:2
Posted: 08-09-05 07:10am
What is your point, paganangel? Are you
saying that ru486 should be taken off the
market because in *rare* cases, it's
caused a woman to die? If that is the
case, then most drugs should be off the
market. Heck, viagra causes more deaths
but I don't see anyone calling for it to
be banned. Of course not - men have to
have the almighty orgasm. [/sarcasm]
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paganangel
Experienced User , Rather EHEALTHy
Joined: 22 Jun 2005 Posts: 377 Location: VA
Posted: 08-09-05 10:29am
msrosie
wrote:
what is your point,
paganangel? Are you saying that ru486
should be taken off the market because in
*rare* cases, it's caused a woman to die?
If that is the case, then most drugs
should be off the market. Heck, viagra
causes more deaths but I don't see anyone
calling for it to be banned. Of course
not - men have to have the almighty
orgasm.
[/sarcasm]
when it's proven that the risks can
outweigh the benifits the medication needs
to be removed from the market. Just like
they did with vioxx. I honestly don't
care what medication it is.
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sandyallen
Extremely EHEALTHy
Joined: 02 Feb 2004 Posts: 4580
Paganangel Posted: 08-09-05 18:00pm
All medications have side effects, I knew
a lady that passed on with aspirin
poisining and there are still a lot that
are unable to take aspirin, just like any
other medication. I really hope you
have to work in the real world one of
these days, like a nurse, research or
social services, then you might see and
understand things a lot differently, maybe
go to war even, I have been thru all of
that and maybe you might be able to
unerstand reality, the real world. Yes,
I am pro-choice and I do care very very
much but you seem to have a listening
problem. You are negative and you would
rather talk someone down instead of trying
to understaand and help someone because of
lack of knowing how and inexperience.
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paganangel
Experienced User , Rather EHEALTHy
Joined: 22 Jun 2005 Posts: 377 Location: VA
Re: Paganangel Posted: 08-10-05 00:00am
sandyallen
wrote:
all medications have side
effects, I knew a lady that passed on with
aspirin poisining and there are still a
lot that are unable to take aspirin, just
like any other medication. I really
hope you have to work in the real world
one of these days, like a nurse, research
or social services, then you might see and
understand things a lot differently, maybe
go to war even, I have been thru all of
that and maybe you might be able to
unerstand reality, the real world. Yes,
I am pro-choice and I do care very very
much but you seem to have a listening
problem. You are negative and you would
rather talk someone down instead of trying
to understaand and help someone because of
lack of knowing how and
inexperience.
i'm sorry that you think you know so much
about me dear. But as a matter of fact I
do happen to work in the real world.
Honestly i'm tired of hearing about your
"life" experience and how we are all
dillusional. You do not know me and
please don't act like you do. As for my
listening it's quiet fine but thanks for
the concern.
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sandyallen
Extremely EHEALTHy
Joined: 02 Feb 2004 Posts: 4580
Posted: 08-10-05 19:28pm
Paganangel, back it up again. I never
said, I do know you and that I want to
know you, I am just stating facts and it
is too bad you cannot handle the truth and
facts. I never said you were dillusional
either. As I said before and I will say
it again, I would like to see this place
get pulled back together like it used to
be before it is shut down. Their are too
many people that want this place shut down
so that they can re-start their places.
This place was good and yet kind of a fun
place at one time
believe it or not and I am not a bad
person and I am sure that you are not
either, so I can just ignore you, just
like I do some of the others here and you
can ignore me and we can both move on.
Good luck to you and yours, but I am sorry
for your bitterness and your
mis-understanding.
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paganangel
Experienced User , Rather EHEALTHy
Joined: 22 Jun 2005 Posts: 377 Location: VA
Posted: 08-10-05 21:19pm
I posted numerous topics to try to get
this board back in order but as long as
pcforme is here that will never happen.
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paganangel
Experienced User , Rather EHEALTHy
Joined: 22 Jun 2005 Posts: 377 Location: VA
Posted: 08-10-05 22:32pm
Oh poor baby. Go and cry now.
You ruined this board troll.
Suffer suffer suffer ;)
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paganangel
Experienced User , Rather EHEALTHy
Joined: 22 Jun 2005 Posts: 377 Location: VA
Posted: 08-11-05 16:24pm
I'm sorry you must have me confused with
your daddy.
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paganangel
Experienced User , Rather EHEALTHy
Joined: 22 Jun 2005 Posts: 377 Location: VA
Posted: 08-12-05 00:16am
Pathetic.
Suffer suffer suffer ;) troll
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paganangel
Experienced User , Rather EHEALTHy
Joined: 22 Jun 2005 Posts: 377 Location: VA
Posted: 08-12-05 09:58am
I'm not spamming any forums...But thanks
for lying. ;)
suffer suffer suffer troll
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paganangel
Experienced User , Rather EHEALTHy
Joined: 22 Jun 2005 Posts: 377 Location: VA
Posted: 08-13-05 01:35am
Suffer suffer suffer troll ;)
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paganangel
Experienced User , Rather EHEALTHy
Joined: 22 Jun 2005 Posts: 377 Location: VA
Posted: 08-13-05 11:58am
You don't really deserve anything
new...But you do deserve to suffer.
