Multiple Sclerosis Forum - Changing From Rebif to Avonex
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Changing From Rebif to Avonex

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Medical Questions-> Health Forums -> Multiple Sclerosis -> Changing From Rebif to Avonex
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dawnbaldwin

New User, Becoming EHEALTHy
Joined: 02 Feb 2006
Posts: 2
Location: Ohio
Changing From Rebif to Avonex
Posted: 02-03-06 09:42am

Can anyone share their experience of changing from rebif to avonex? After 5 years on rebif, I have developed nabs (neutralizing antibodies). My neurologist wants to switch me to avonex. I'm concerned about the efficacy since it is still an interferon ... And will I likely start all over with side effects? Any experiences out there?
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Lucille7

New User, Becoming EHEALTHy
Joined: 13 Mar 2006
Posts: 2
Neutralizing Ab's
Posted: 03-13-06 20:46pm

What symptoms did you have leading your physician to order the screen? Were you having symptoms or are/were more active lesions showing up?

I have recently started using therapy. There is only one lab that actually performs this test. Did your physician do a baseline or just decide that since you were not (i assume) improving that ordering a $900 test which would show the presence of these antibodies proves a correlation.

I don't know either, but switching to another interferon is a crapshot. If your neurologist is really concerned about this issue he/she should switch you to another class of drugs that do not run the risk of neutralizing antibodies....Jeez---i had to make like eight calls to find out about this test, convince both the insurance company and my physician they should perform a baseline test....And then, what is the rational behind all this?

No disrespect intended, but docs---give us an informed opinion on this stuff and some good studies on this issue please---otherwise ms patients will spend $$$ needlessly.
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