Parkinson Disease Forum - Secondary And Primary


Secondary And Primary

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BAILEYBB

New User, Becoming EHEALTHy

Joined: 17 Oct 2006
Posts: 2
Location: Edson

Secondary And Primary Posted: 10-20-06 15:40pm


Does anybody no the difference between secondary and primary parkinson's disease. I know that secondary pd is when there is a known source that caused it but are they still the same thing just one with a cause and the other with the cause unknown?

Dr. Nikola

Doctor

Joined: 01 Apr 2008
Posts: 802
Location: Strumica, Republic of Macedonia

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Posted: 04-15-08 07:38am


In both primary and secondary Parkinson, dopaminergic neurons located in the substantia nigra of the corpus striatum are destroyed so there the same symptoms are present. In primary Parkinson (Parkinson disease) the reason for progressive dying of those neurons is unknown. One of the possible hypothesis is that those neurons normally dies with aging but some people are born with less dopaminergic neurons in the substantia nigra so when they become older they are missing those neurons more than the rest of the normal people. In secondary Parkinson (Parkinson syndrome) dopaminergic neurons in the substantia nigra can be destroyed by various known reasons like brain infection, cerebro-vascular insult (stroke), cerebral atherosclerosis, brain trauma, poisoning with heavy metals or pesticides etc. Beside Parkinson symptoms there can be also present some other symptoms typical for the primary disorder. For example, high temperature in brain infection.

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