Clomid is an estrogen blocker that is used
as an ovulation stimulator. Clomid acts on
the hypothalamus by blocking its estrogen
receptors. Without estrogen stimulation,
the hypothalamus begins to secrete more
GnRH that, in turn, stimulates the
pituitary gland to increase secretion of
FSH and LH. FSH and LH stimulate the
growth of ovarian follicles and ovulation.
Prometrium is synthetic progesterone. The
ovaries normally produce progesterone in
the second phase of the menstrual cycle,
after the ovulation. More precisely,
progesterone is produced by the yellow
body (corpus luteum)-a structure that
originates from the ovarian follicle after
ovulation. Progesterone prepares the
endometrium for implantation of a
fertilized egg-cell. The yellow body
produces progesterone in the first 2-3
months of pregnancy. After that time, the
placenta continues to produce progesterone
itself. There are rare cases of yellow
body failure when the yellow body stops
producing progesterone in the early stages
of pregnancy . Yellow body failure can
lead to miscarriage. Prometrium is given
as a supplementary therapy to prevent
miscarriage in case of yellow body
failure. You can start taking prometrium
after ovulation. If you don’t get
pregnant, you should then stop taking
prometrium.
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